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April 1963


Arch Dermatol. 1963;87(4):532-535. doi:10.1001/archderm.1963.01590160124026

Discoid Lupus Erythematosus: Question of Therapy. Presented by Dr. Troy G. Rollins.

A 38-year-old woman has had an erythematous indurated plaque on her left cheek for 12 years. The cosmetic appearance bothers her tremendously. She received treatment in 1956, 1958, and 1959. In 1956 complete physical examination, including kidney function studies, serology, lupus erythematosus preparation, blood cell count, creatine clearance, phenolsulfonphthalein test (PSP), and intravenous pyelogram (IVP) were entirely normal. A biopsy of the lesion at that time was read as discoid lupus erythematosus (LE). She stated that in 1958 she was treated with chloroquine with no results and then switched to amodiaquine (Camoquim) with progressive improvement. Local injections of cortisone had no effect. Subsequently she was taken off the amodiaquine, because of pigmentation of the fingernails and palate, and soon observed a recurrence of the lesion.

In October of 1960 the patient was placed on hydroxychloroquine (Plaquenil), 200 mg.,