A cytopathogenic effect was observed when molluscum contagiosum suspensions from 12 patients were passed into monolayer tissue cultures of monkey kidney, primary human amnion, and the F1 line of human amnion cells. Cytopathogenicity was associated with giant cell production as well as individual cell changes. Acidophilic, desoxyribonucleic acid-containing cytoplasmic inclusion bodies were identified in both acridine orange and Giemsa-stained preparations.
Antibodies demonstrated by the fluorescent antibody technique reacted specifically with the inclusion bodies. An attempt to infect a human being with virus-containing tissue culture material did not result in the production of overt disease.
RASKIN J. Molluscum Contagiosum: Tissue Culture and Serologic Study. Arch Dermatol. 1963;87(5):552–559. doi:10.1001/archderm.1963.01590170010002
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