[Skip to Content]
[Skip to Content Landing]
May 1963

Drug Eruptions From Anticonvulsant DrugsObservations on Drug-Induced Lesions That Were Fixed and Lupus-Erythematosus-Like, and on Cross-Reactivity Between Several Drugs Involved

Arch Dermatol. 1963;87(5):612-617. doi:10.1001/archderm.1963.01590170070012

Two cases are reported of cutaneous and systemic reactions due to hydantoin type drugs and phenobarbital. The manifestations in part were characteristic for a fixed drug eruption and in part for a subacute lupus-erythematosus-like syndrome. Cross-sensitization among a number of hydantoin type drugs and phenobarbital was demonstrated.