Two cases are reported of cutaneous and systemic reactions due to hydantoin type drugs and phenobarbital. The manifestations in part were characteristic for a fixed drug eruption and in part for a subacute lupus-erythematosus-like syndrome. Cross-sensitization among a number of hydantoin type drugs and phenobarbital was demonstrated.
GOLDSTEIN N, LEIDER M, BAER RL. Drug Eruptions From Anticonvulsant Drugs: Observations on Drug-Induced Lesions That Were Fixed and Lupus-Erythematosus-Like, and on Cross-Reactivity Between Several Drugs Involved. Arch Dermatol. 1963;87(5):612–617. doi:10.1001/archderm.1963.01590170070012
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