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May 1963

Hydroa Vacciniforme

Arch Dermatol. 1963;87(5):618-625. doi:10.1001/archderm.1963.01590170076013

Hydroa vacciniforme is a recurrent vesicular disease that affects light-exposed cutaneous surfaces upon which the ravages of prior episodes are disclosed by scars. Because confusion with porphyria has invalidated past reviews, this review concerns a series of 29 cases in which clinical or biochemical evidence of porphyria was absent. The onset occurs predominantly (90%) in childhood, and the disease has a 2 to 1 predilection for males. A chronic course is customary. Follow-up information from four patients provides the first recorded confirmation of the impression that the disease tends to be selflimited.