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Article
May 1963

DIFFUSE NORMOLIPEMIC PLANE XANTHOMA

Author Affiliations

115A Harley St, W1 London

Arch Dermatol. 1963;87(5):654. doi:10.1001/archderm.1963.01590170112022

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Abstract

To the Editor: I was extremely interested in the report by Drs. Altman and Winkelmann entitled "Diffuse Normolipemic Plane Xanthoma" (Arch Derm 85: 633, 1962).

The patient of mine which they quote died at the age of 50 of congestive heart failure, 18 years after the onset of her cutaneous lesions. At postmortem examination very severe atheromatous change was found in the aorta, with ulceration and aneurysm formation. The esophagus and intestine were lined throughout by an orange-yellow lipoid deposit which could be seen from both the peritoneal and mucosal surfaces. The mesentery also contained this orange-yellow lipoid in place of the normal pale yellow fat. Microscopic examination further showed cholesterol emboli in some of the arteries of the kidneys, a large atheromatous plaque in the cerebral artery, and collections of foam cells in the choroid plexus, muscle, and bone marrow. No evidence of myelomatosis was found.

These findings suggest

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