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June 1963

Eccrine Function During Therapy of Psoriasis: Paradoxical Sweating on and Around Psoriatic Lesions During Topical Therapy by Fluocinolone Acetonide and Plastic Films

Author Affiliations


Research Assistant, Department of Medicine (Dermatology) Shaughnessy Hospital (Dr. Buck); Clinical Instructor in Medicine (Dermatology), University of British Columbia (Dr. Mitchell).

Arch Dermatol. 1963;87(6):696-700. doi:10.1001/archderm.1963.01590180024005

Untreated psoriatic lesions were anhidrotic following methacholine and thermal stimuli but, during therapy with fluocinolone acetonide and occlusive plastic films, delivery of sweat to the surface of the psoriatic lesion began to occur after therapy for more than seven days. Concurrently, the clinically uninvolved skin which surrounded the lesion became anhidrotic at the site of the occlusive dressing. Sweat retention in psoriasis could not be provoked even when the local conditions were such that anhidrosis occurred in adjacent `normal' skin. The reasons for anhidrosis in adjacent clinically `normal' occluded skin were not clear since miliaria could not be demonstrated. Sweating at the site of an occluded psoriatic lesion could be induced by consecutive application of methacholine and thermal stimuli when either of these stimuli given alone was ineffective. The onset of sweating a short time after the start of effective therapy did not suggest that nerve degeneration might be responsible for anhidrosis in psoriasis.