Oral versus intramuscular methylprednisolone suspension was studied by a double-blind placebo method. Eczema patients were used because they were adaptable to the study. The corticosteroid was administered for six weeks to each patient who completed the study. These dosage schedules were used: 40 mg of methylprednisolone suspension intramuscularly every week versus 2-2-2 mg orally, daily, and 60 mg of methylprednisolone suspenson intramuscularly each week versus 4-2-2 mg of the oral drug.
There were no significant differences in average improvement among the four groups above. No serious reactions were observed. Early relapses occurred in all groups.
In conclusion, there appeared to be no significant difference in clinical result between oral and intramuscular administration.
STROUD GM, MILLER RE, KOZIKOWSKI ES. Oral Versus Intramuscular MethylprednisoloneA Double-Blind Study. Arch Dermatol. 1963;87(6):710–714. doi:10.1001/archderm.1963.01590180038008
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