A new concept of the function of the stratum corneum in percutaneous transfer is presented. Topically applied steroids forced into this layer by occlusion for a few hours with Saran Wrap remain for up to two weeks. Their presence can be demonstrated by the development of a physiological marker— vasoconstriction—after repeated occlusion with Saran. The reservoir is in the stratum corneum, as material injected intradermally does not produce a reservoir, no reservoir is demonstrable on skin stripped of the stratum corneum, and a reservoir established on unstripped skin can be destroyed by stripping the area.
VICKERS CFH. Existence of Reservoir in the Stratum Corneum: Experimental Proof. Arch Dermatol. 1963;88(1):20–23. doi:10.1001/archderm.1963.01590190026002
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