This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
Melanoplakia. Presented by Dr. Alfred W. Kopf.
A 62-year-old woman developed a dark "spot" on the vermilion of the lower lip about 18 months ago. Since then a number of similar areas of hyperpigmentation have appeared in the same region. Her dentist states that silver nitrate had not been used in the dental work he performed recently.
The patient presents several light tan, macular, irregularly outlined areas of discoloration, 3 to 6 mm in diameter, on the vermilion of the lower lip and near each commissure.
Biopsy of a lesion revealed hyperpigmentation of the basal layer, most pronounced at the tips of the rete ridges, but no evidence of nevus cells. Numerous melanophages were seen in the upper cutis.
X-ray examination of the gastrointestinal tract showed no evidence of polyps anywhere.
Dr. Alfred W. Kopf: Macular, tan to darkbrown or black lesions of the vermilion and buccal mucosa are
Biberstein HH, Silver H, Leider M. THE BRONX DERMATOLOGICAL SOCIETY. Arch Dermatol. 1963;88(1):85–91. doi:10.1001/archderm.1963.01590190091017
Customize your JAMA Network experience by selecting one or more topics from the list below.