This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
This small volume is an excellent and concise account of our present knowledge of porphyrin metabolism and the porphyrias, human and animal, natural and experimental. One chapter is devoted to the chemistry of the porphyrins, their distribution in nature, and their vital role in cellular physiology, particularly in the biosynthesis of heme. In the process of the formation of hemoglobin, a protein-bound form of iron reacts with a protein-bound form of protoporphyrin through a series of enzymatically controlled stages to produce heme. Deviations from these pathways, through a genetic fault or under the influence of tissue poisons, bring about the various forms of porphyria.
Watson's classification of the types of the disease is brought up to date with a complete description of the clinical, genetic, and chemical distinctions of each form, including the newest erythropoietic protoporphyria as well as the toxic porphyria of the unfortunate young Turks that followed the
Brunsting LA. Diseases of Porphyrin Metabolism. Arch Dermatol. 1963;88(1):107. doi:10.1001/archderm.1963.01590190113023
Dermatology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.