Patients with a variety of hand dermatoses were removed from their work milieu, hospitalized, and their hands exposed exclusively to repeated daily immersion in two alkaline household washing products. The majority of subjects improved during the test. It was observed that the response of the hand immersed in the washing product paralleled the response of the control hand, which was exposed to tap water of the same temperature. From these observations it was concluded that in household usage soap or synthetic detergent immersion alone may not be the primary provoking stimulus in housewives' dermatitis. The role of other critical factors such as temperature and humidity are discussed.
SUSKIND RR, MEISTER MM, SCHEEN SR, REBELLO DJA. Cutaneous Effects of Household Synthetic Detergents and Soaps. Arch Dermatol. 1963;88(2):117–124. doi:10.1001/archderm.1963.01590200005001
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