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August 1963

Vogt-Koyanagi-Harada Syndrome

Arch Dermatol. 1963;88(2):146-149. doi:10.1001/archderm.1963.01590200034006

The clinical findings in the Vogt-Koyanagi-Harada syndrome are reviewed and a case reported emphasizing the cutaneous changes. The syndrome consists of symptoms of meningeal irritation, nontraumatic uveitis, poliosis, vitiligo, alopecia, and dysacousia. Meningeal or ocular symptoms usually appear first, but in some patients the cutaneous changes have been observed before the uveitis. The etiology remains unsettled, but an allergic mechanism or a virus infection is favored by most observers. Early diagnosis is important because ocular morbidity can be reduced significantly in some patients if treated in the early stages.