The second case of hyperkeratosis follicularis et parafollicularis in cutem penetrans (Kyrle's disease) is reported. The nature of the keratin mass in the dermis is shown by the dihydroxyl-dinaphthyl disulfide stain for sulfhydryl groups which is positive in the case presented.
PETERSON WC, GOLTZ RW, HULT A. Hyperkeratosis Penetrans (Kyrle's Disease). Arch Dermatol. 1963;88(2):210–214. doi:10.1001/archderm.1963.01590200098020
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