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August 1963

Hyperkeratosis Penetrans (Kyrle's Disease)

Author Affiliations


Division of Dermatology, Department of Medicine, University of Minnesota Hospitals.

Arch Dermatol. 1963;88(2):210-214. doi:10.1001/archderm.1963.01590200098020

The second case of hyperkeratosis follicularis et parafollicularis in cutem penetrans (Kyrle's disease) is reported. The nature of the keratin mass in the dermis is shown by the dihydroxyl-dinaphthyl disulfide stain for sulfhydryl groups which is positive in the case presented.