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Peutz-Jeghers' Syndrome. Presented by Dr. Willard M. Meininger.
A 71-year-old woman had "brown spots" on her lips since 1960. She is unaware of any similar condition in the family. Her father died of a carcinoma of the colon at age 64, but she does not believe he had hyperpigmentation of his lips.
During October of 1960 she complained of fatigue and bloody stools. Gastrointestinal series and barium enema revealed the presence of a hiatus hernia, a duodenal diverticulum, and polyp in both the sigmoid and transverse colon. A previous barium enema in January, 1959, had failed to reveal any abnormalities. Both polyps were removed; the lesion in the sigmoid colon proved to be an adenocarcinoma, and the transverse colon polyp showed premalignant hyperplasia.
Dr. Edward J. Ringrose: I saw a woman with similar spots on her lips. She was referred by a general practitioner. She had been on corticosteroids
Behling RT, Epstein JH, Bennett JH. SAN FRANCISCO DERMATOLOGICAL SOCIETY. Arch Dermatol. 1963;88(2):235–237. doi:10.1001/archderm.1963.01590200123032
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