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September 1963

Multiple Nonpigmented Nevi in a Negro ChildPossible Relationship to Leukoderma Acquisitum Centrifugum (Halo Nevus)

Arch Dermatol. 1963;88(3):313-319. doi:10.1001/archderm.1963.01590210071010

A two-year-old Negro patient with multiple nonpigmented nevi is reported. Our histopathological and histochemical studies indicate an active melanin-producing system within the nevus cells. Hypopigmentation and failure of the lesions to repigment may be due to a defect in melanogenesis or faulty transfer of melanin to epidermal cells. Rapid dropping off of pigment into the corium may be another contributory factor.