A two-year-old Negro patient with multiple nonpigmented nevi is reported. Our histopathological and histochemical studies indicate an active melanin-producing system within the nevus cells. Hypopigmentation and failure of the lesions to repigment may be due to a defect in melanogenesis or faulty transfer of melanin to epidermal cells. Rapid dropping off of pigment into the corium may be another contributory factor.
JAMES H. GRAHAM, NORMAN A. FOGEL, CARROLL F. BURGOON. Multiple Nonpigmented Nevi in a Negro ChildPossible Relationship to Leukoderma Acquisitum Centrifugum (Halo Nevus). Arch Dermatol. 1963;88(3):313–319. doi:10.1001/archderm.1963.01590210071010