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October 1963

Photo-Irradiation Studies of Two Tetracyclines: Tetracycline and Demethylchlortetracycline

Author Affiliations


From the Department of Dermatology, University of Miami School of Medicine, Miami, and the Veterans Administration Hospital, Coral Gables, Fla.

Arch Dermatol. 1963;88(4):440-444. doi:10.1001/archderm.1963.01590220072008

Both tetracycline (TET) and demethylchlortetracycline (DMC) are photosensitive substances under the conditions of this experiment.

Ultraviolet wavelengths which pass through common window glass (>315 mμ) will activate this response in human skin.

DMC appears to have greater photoresponse potential per unit concentration than tetracycline.

A hot quartz lamp appears to be an inadequate light source for these studies, when compared with natural sunlight.

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