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Article
November 1963

Micosis Profundas

Arch Dermatol. 1963;88(5):670. doi:10.1001/archderm.1963.01590230178025

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Abstract

In 1940 Pablo Negroni published his mycologic studies of the first case of histoplasmosis in South America. Since then his world-wide reputation for scholarly and thorough work presented with lucidity and judgement has steadily grown. The present monograph, for these who read Spanish, is an excellant review of the subject.

Samuel T. Darling discovered the disease in Panama in 1905 while trying to confirm the hypothesis of Manson and Ross that leishmaniasis existed in America. He thought that it was a protozoa, but the Brazilian parasitologist, Da Rocha Lima, working in Hamburg in 1913 reviewed Darling's slides and first suggested that it was a fungus. Twenty years passed before the next cases were reported, and these were all in the United States. De Monbreun in 1934 proved the organism a fungus, fulfilled Koch's postulates, and noted its dimorphic phases: filamentous at 27 C and yeast or parasitic at 37 C.

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