We have shown that:
Regional lymphadenectomy in guinea pigs markedly reduces the frequency of sensitization to contact allergens.
Periumbilical application of allergen regularly results in lower frequencies of contact sensitization than similar exposures on the arm.
Multiple simultaneous application of allergen to one extremity gives a greater frequency of contact sensitization than an equal number of exposures scattered over three extremities.
Repeated application of allergen to one extremity produces a greater frequency of contact sensitization than the same number of exposures each on a different limb or body area.
These findings verify the work of Frey and Wenk and support the idea that the regional lymph nodes play a crucial role in contact sensitization, especially to weak allergens. This concept can be used to advantage in planning predictive patch tests for industrial and cosmetic sensitizers.
EPSTEIN WL, KLIGMAN AM, SENECAL IP. Role of Regional Lymph Nodes in Contact Sensitization. Arch Dermatol. 1963;88(6):789–792. doi:10.1001/archderm.1963.01590240113019
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