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December 1963

Lack of Correlation Between EEG Abnormalities and Anaphylactic Response

Author Affiliations


From the Allergy Research Laboratory and the Department of Dermatology, Karolinska Sjukhuset, Stockholm; the Nobel Institute for Neurophysiology, Karolinska Institutet, Stockholm; and the Department of Psychiatric Neurophysiology, Psychiatric Research Centre, Ulleråker, Sweden.

Arch Dermatol. 1963;88(6):793-798. doi:10.1001/archderm.1963.01590240117020

The EEG and the behavior of actively sensitized animals were compared during the anaphylactic reaction provoked with low, intraperitoneal shock doses of either horse serum or recrystallized egg albumin. It was found that the recording of the electrical cortical activity does not provide a good index of the anaphylactic reaction; however, it has been shown that a group of animals can indeed have severe abnormalities in their EEG when subjected to a challenging dose with only minor signs of behavioral disturbance. The abnormalities in the cortical activity have been interpreted as an isolated partial symptom of the anaphylactic reaction. Another extreme group of animals showed the classical anaphylactic response with only a late effect on the EEG, secondary to the impairment of respiration and the systemic circulation. Other animals occupied an intermediate position or did not respond to the challenge. Further details will be presented elsewhere in the future.1

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