Corynebacterium acnes injected into sterile steatocystomas proliferate vigorously and convert these quiescent cysts into inflammatory lesions through rupture of the wall. It is proposed that the organism is responsible for a similar sequence in the comedones of acne vulgaris.
KIRSCHBAUM JO, KLIGMAN AM. The Pathogenic Role of Corynebacterium Acnes in Acne Vulgaris. Arch Dermatol. 1963;88(6):832–833. doi:10.1001/archderm.1963.01590240156026
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