Corynebacterium acnes injected into sterile steatocystomas proliferate vigorously and convert these quiescent cysts into inflammatory lesions through rupture of the wall. It is proposed that the organism is responsible for a similar sequence in the comedones of acne vulgaris.
J. O. KIRSCHBAUM, A. M. KLIGMAN. The Pathogenic Role of Corynebacterium Acnes in Acne Vulgaris. Arch Dermatol. 1963;88(6):832–833. doi:10.1001/archderm.1963.01590240156026