In this survey, 103 consecutive patients with psoriasis were studied with respect to their (1) oral glucose tolerance tests, (2) family history of diabetes mellitus and/or psoriasis, and (3) urinalyses.
Using conservative diagnostic criteria, 25% of these 103 psoriatic patients were found to have diabetes. The statistical possibility that this observation resulted from chance alone was less than 1 in 2,000 (P<0.0005). This probability is so remote that the negative thesis should be discarded, and a positive degree of association between diabetes mellitus and psoriasis must be seriously considered.
The family histories of these same 103 psoriatic patients revealed the frequent occurrence of diabetes and psoriasis in their relatives. The probability that these frequencies occurred in an independent manner is less than I in 50 (ie, between P>0.01 and <0.025). Therefore this thesis of independence is rejected, and some degree of relationship should be considered.
REEDS RE, FUSARO RM, FISHER I. Psoriasis Vulgaris: I. A Clinical Survey of the Association With Diabetes Mellitus. Arch Dermatol. 1964;89(2):205–208. doi:10.1001/archderm.1964.01590260043007
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