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March 1964

Secondary Hypertrophic Osteoarthropathy and Acanthosis Nigricans: Restudy of a Case Simulating Pachydermoperiostosis

Author Affiliations


Instructor in Medicine (Dermatology), University of Southern California.

From the Department of Medicine (Dermatology), University of Southern California School of Medicine.

Arch Dermatol. 1964;89(3):328-333. doi:10.1001/archderm.1964.01590270014003

A unique case, briefly reported eight years ago as pachydermoperiostosis associated with acanthosis nigricans, is reviewed and the earlier diagnosis clarified. In the light of recent studies which have evolved more definitive terminology and the concept of dysacromelias, the original classification is no longer tenable, and the case must now be regarded as an acromegaloid variant of secondary (pulmonary) hypertrophic osteoarthropathy associated with malignant acanthosis nigricans. Although autopsy findings confirmed certain clinical impressions, many aspects still remain unclear and suggest the possibility of spontaneous regression. Total leukonychia, a striking finding in this case, has not heretofore been observed with hypertrophic osteoarthropathy.