Chemical analysis of dermis from scleroderma revealed a normal concentration of water and hydroxyproline. This last finding suggest no increase in collagen. Moreover, x-ray diffraction patterns and amino acid analysis of collagen fibers disclosed no abnormalities. My findings support the hypothesis that the main abnormality in scleroderma probably lies in the ground substance.
FLEISCHMAJER R. The Collagen in Scleroderma. Arch Dermatol. 1964;89(3):437–441. doi:10.1001/archderm.1964.01590270123028
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