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March 1964

The Collagen in Scleroderma

Author Affiliations


Post-doctoral fellow of the Arthritis and Rheumatism Foundation.

Present Address: Hahnemann Medical College and Hospital, 230 N Broad St, Philadelphia 2, Pennsylvania.

From the Department of Biochemistry, College of Dentistry and the Department of Dermatology, School of Medicine, New York University.

Arch Dermatol. 1964;89(3):437-441. doi:10.1001/archderm.1964.01590270123028

Chemical analysis of dermis from scleroderma revealed a normal concentration of water and hydroxyproline. This last finding suggest no increase in collagen. Moreover, x-ray diffraction patterns and amino acid analysis of collagen fibers disclosed no abnormalities. My findings support the hypothesis that the main abnormality in scleroderma probably lies in the ground substance.

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