In this paper 133 patients on long-term high doses of corticosteroids have been divided into four age groups, and data have been presented relating to development of acne, hypertrichosis, and facial oiliness in each of these groups. It has been shown that prepubertal children apparently do not develop acneiform lesions or oiliness of facial skin as a result of corticosteroid therapy, but that hypertrichosis often occurs in these patients. It has also been shown that there is no significant sexual or racial difference in the development of these steroid complications. It is suggested that the production of hypertrichosis and acneiform lesions by corticosteroids is not dependent on the androgenic activity of the steroids.