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March 1964


Arch Dermatol. 1964;89(3):485-491. doi:10.1001/archderm.1964.01590270171043

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Congenital Ichthyosiform Erythroderma. Presented by Dr. Walter F. Lever.  An American boy aged 11 has from birth been covered with thick scales which are especially pronounced on the flexor surfaces of the extremities. Blisters were also present until the age of 18 months. Past treatment had consisted of low doses of vitamin A for one year and Polysorb ointment topically. The family history is noncontributory except for the presence of a similar condition in his brother.Examination in April, 1962, showed large, thick, hyperkeratotic scales which were especially noticeable on the flexor surfaces, but which included the entire trunk, extremities, and face. Erythema accompanied the scaling of the face and extremities.Hypertonic saline baths were prescribed, with Domolene-HC creme to the face and Polysorbointment to the remainder of the body. No change in the eruption occurred by June. At this time 400,000 units of vitamin A by mouth was begun.

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