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April 1964

Parenteral Methotrexate in Psoriasis

Author Affiliations


Dermatology Branch, National Cancer Institute, National Institutes of Health, Public Health Service, US Department of Health, Education, and Welfare.

Present address: 909 Fifth Ave, New York (Dr. Auerbach).

Arch Dermatol. 1964;89(4):550-556. doi:10.1001/archderm.1964.01590280050009

This report discusses the biochemical, biological, and pharmacological actions of folic acid antagonists on the lesion of psoriasis and other tissues of the body.

Clinical experience and results in the treatment of psoriasis with parenteral methotrexate are reviewed. Weekly to biweekly injections of the drug were found to maintain improvement of the disease.

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