This report describes the influence of the vehicle base of an applied topical steroid on the therapeutic efficacy of the medication.
Fluocinolone acetonide in a 0.025% concentration was the steroid used. This was applied in a cream (a water-washable aqueous base of stearic acid, propylene glycol, sorbitan monostearate and mono-oleate, polyoxyethylene sorbitan monostearate with methyl and propylparaben as preservatives)* and an ointment (white petrolatum)† vehicle. Fluocinolone acetonide has been shown to be therapeutically effective when utilized topically in the treatment of psoriasis and eczematous dermatoses.1-5
Eighteen patients with psoriasis and 32 patients with atopic, contact, seborrheic, hypostatic, or nummular dermatitis were included in the study.
The cream and ointment preparations were applied in two ways: simultaneous paired comparison, and alternating consecutive weekly trial usage. Each trial comparison was judged at weekly intervals. In instances where Saran wrap was used, the cream and ointment applications were exactly matched. Where indicated
BLEIBERG J, BRODKIN RH. Therapeutic Efficacy of Fluocinolone Acetonide Ointment and Cream. Arch Dermatol. 1964;89(4):561. doi:10.1001/archderm.1964.01590280061012
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