The innervation of the skin was studied in ten patients with lichen simplex chronicus using an improved silver impregnation technique. Significant changes were present in all cases, and consisted of an increase in the rate of "neural turnover" and a proliferation of Schwann cells. These Schwann cells made up a large proportion of the cellular infiltrate seen in routine histological preparations. Clinically normal skin from the same patients showed similar, though less marked, abnormalities in several instances. The neurohistological picture could be distinguished easily from that in psoriasis.
COWAN MA. Neurohistological Changes in Lichen Simplex Chronicus. Arch Dermatol. 1964;89(4):562–568. doi:10.1001/archderm.1964.01590280062013
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