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April 1964


Arch Dermatol. 1964;89(4):604-614. doi:10.1001/archderm.1964.01590280104019

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Chronic Ulceration of Mouth and Throat and Difficulty in Swallowing. Presented by Charles Frank Post, MD. 

History.—  The patient was of Italian-Jewish extraction, male, age 43. In February, 1960, the patient was given penicillin and oral antibiotics for an attack of "flu." A few days later he developed "canker sores in the mouth" which progressed to form large, painful necrotic ulcers of the palate, pharynx, tongue, and buccal mucous membrane. This attack subsided by August, 1960, In October, 1961, a second severe attack began which persisted until February, 1962. The disease has been inactive for one year. The patient has had oral "canker sores" since childhood. His mother died at 53 of leukemia, and his father died at 40 of a coronary occlusion.

Examination.—  There is pronounced scarring and tissue loss of the soft palate with contraction and lack of control of palatal movement. There is a

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