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April 1964


Arch Dermatol. 1964;89(4):625. doi:10.1001/archderm.1964.01590280125022

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Allergic Vasculitis From Drug? Presented by Dr. Frank E. Cormia. 

History.—  The patient is a 46-year-old white woman whose present condition began 13 years ago with a few small flat erythematous macules on the legs. These gradually increased in number up until five years ago, since which time there have been about 40 lesions consistently present over the legs. The duration of the individual lesions is unknown, but the course is indolent. There is some itching. She has taken dextro amphetamine, 10 to 15 mg daily, since before the onset of the lesions.

Examination.—  Scattered over both legs are peculiar erythematous and scaly macules of from 4 to 8 mm in diameter. Some are diffusely reddish, some are annular in character, and others are slightly depressed and possibly atrophic.

Biopsy.—  "Vasculitis (nonspecific) The epidermis is not involved in the process. In the upper dermis, the capillaries are dilated and thickened

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