Betamethasone and 23 of its esters and ortho-esters, assayed topically on healthy human subjects, had vasoconstrictor activities ranging from 0.1% to 400% of that of a standard steroid, fluocinolone acetonide. Compared with the standard in ointments, betamethasone 17,21 - methyl - ortho - valerate and betamethasone 17-valerate showed promising activity in the occlusion treatment of psoriasis. It is concluded that, despite its low precision, the vasoconstriction assay is of value for screening potential topically active anti-inflammatory steroids.
Vasoconstriction assays should be designed to allow for differences in sensitivity between subjects and between sites of steroid application.
McKENZIE AW, ATKINSON RM. Topical Activities of Betamethasone Esters in Man. Arch Dermatol. 1964;89(5):741–746. doi:10.1001/archderm.1964.01590290107016
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