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May 1964

Topical Activities of Betamethasone Esters in Man

Author Affiliations


St. John's Hospital for Diseases of the Skin, Lisle St, London WC 2 (Dr. McKenzie); Glaxo Research Ltd., Greenford, Middlesex (Dr. Atkinson).

Arch Dermatol. 1964;89(5):741-746. doi:10.1001/archderm.1964.01590290107016

Betamethasone and 23 of its esters and ortho-esters, assayed topically on healthy human subjects, had vasoconstrictor activities ranging from 0.1% to 400% of that of a standard steroid, fluocinolone acetonide. Compared with the standard in ointments, betamethasone 17,21 - methyl - ortho - valerate and betamethasone 17-valerate showed promising activity in the occlusion treatment of psoriasis. It is concluded that, despite its low precision, the vasoconstriction assay is of value for screening potential topically active anti-inflammatory steroids.

Vasoconstriction assays should be designed to allow for differences in sensitivity between subjects and between sites of steroid application.