Seven cases of scleroderma were selected for this study.
Electrophoresis of serum proteins showed a moderate reduction in albumins and a slight increase in the γ-globulins; probably neither finding is very significant. In all cases the α2-globulins were increased while the β-globulins were reduced; thus the β/α2-globulin ratio was decreased.
Serum hexosamine levels were usually increased in scleroderma. Electrophoresis of serum glycoproteins revealed a consistent increase of the α2 glycoproteins.
During the remission stage of the disease an increase was noted in the albumins and in the ratio of the β- to α2-globulin fractions. The α1- and α2-glycoproteins showed a mild tendency to decrease.
FLEISCHMAJER R. Serum Proteins and Glycoproteins in Scleroderma. Arch Dermatol. 1964;89(5):749–753. doi:10.1001/archderm.1964.01590290115018
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