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May 1964

Serum Proteins and Glycoproteins in Scleroderma

Author Affiliations


Post-doctoral fellow of the Arthritis and Rheumatism Foundation.

Present address: Hahnemann Medical College and Hospital, 230 N Broad St, Philadelphia, Pa 19102.

From the Department of Biochemistry, College of Dentistry and the Department of Dermatology, School of Medicine, New York University.

Arch Dermatol. 1964;89(5):749-753. doi:10.1001/archderm.1964.01590290115018

Seven cases of scleroderma were selected for this study.

Electrophoresis of serum proteins showed a moderate reduction in albumins and a slight increase in the γ-globulins; probably neither finding is very significant. In all cases the α2-globulins were increased while the β-globulins were reduced; thus the β/α2-globulin ratio was decreased.

Serum hexosamine levels were usually increased in scleroderma. Electrophoresis of serum glycoproteins revealed a consistent increase of the α2 glycoproteins.

During the remission stage of the disease an increase was noted in the albumins and in the ratio of the β- to α2-globulin fractions. The α1- and α2-glycoproteins showed a mild tendency to decrease.

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