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May 1964

Neurohistological Changes in Prurigo Nodularis

Author Affiliations


Present address St. John's Hospital for Diseases of the Skin, Lisle Street, Leicester Square, London, W.C. 2, England.

From Department of Dermatology, United Oxford Hospitals, England, and University of Oregon Medical School, Portland, Ore.

Arch Dermatol. 1964;89(5):754-758. doi:10.1001/archderm.1964.01590290120019

The innervation of a nodule from a patient with prurigo nodularis was studied using the improved silver impregnation technique of Richardson (1960). Profound changes were seen in nerve fibers, where there was a very marked acceleration in the rate of "turnover," and in Schwann cells, where there was hyperplasia and schwannoma formation. A possible peripheral neural relationship was noted between prurigo nodularis and lichen simplex chronicus.

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