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June 1964

Steroid Aerosol Spray In Contact Dermatitis: Prophylactic Use With Particular Reference to Nickel Hypersensitivity

Author Affiliations


From the Department of Dermatology, New York University Schools of Medicine and The Skin and Cancer Unit, University Hospital, New York.

Arch Dermatol. 1964;89(6):841-843. doi:10.1001/archderm.1964.01590300069020

Barrier creams and protective ointments have proved to be of rather limited value in protecting the skin against irritants and sensitizers. For the past year it has been found that a film formed by spraying the skin with topical aerosol dexamethasone (Decadron) spray* is effective in preventing dermatitis in individuals who would otherwise manifest allergic eczematous contact dermatitis from nickel-plated objects. A 90-gm tube of this spray contains 10 mg of dexamethasone; isopropyl myristate; and Freon propellants: trichloromonofluromethane and dichlorodifluoromethane.

According to the manufacturer each second of spray at 6 inches distance dispenses 0.75 mg of dexamethasone, a synthetic analogue of hydrocortisone.

The isopropyl myristate in this spray is a synthetic fatty oily compound which acts as a residual film after the Freon has evaporated. This fatty acid ester is used in many cosmetics as a lubricant and skin emollient in 2% to 10% concentration. The film formed by the

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