Prevention of recurrent herpes simplex, despite numerous recommended procedures, has remained a problem. In one of our previous studies, inoculation with a nonspecific vaccine gave results no better than those with the same vaccine which had been heatinactivated. It appeared possible that a specific vaccine might produce greater benefit. A double-blind study has recently been conducted in which one group of patients with recurrent herpes simplex received a series of injections of a specific herpes virus vaccine while the control group was given a placebo solution. No significant difference between the results in the two groups was obtained. It is concluded that the benefit observed is attributable to psychotherapeutic effects.
KERN AB, SCHIFF BL. Vaccine Therapy In Recurrent Herpes Simplex. Arch Dermatol. 1964;89(6):844–845. doi:10.1001/archderm.1964.01590300072021
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