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To the Editor:
In view of the increasing use of oral contraceptive drugs in the treatment of acne vulgaris in females, I believe it is important to bring to the attention of all dermatologists the fact that these medications, containing a relatively high dose of estrogen, can effect epiphyseal closure and cessation of growth. High doses of estrogen have in fact been used for this purpose in unusually tall girls; the epiphyseal closure may occur after only a few months of medication, and is of course irreversible. For this reason it is imperative not to use these medications in adolescent girls in whom further skeleton growth is desirable.