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To the Editor:
In view of the increasing use of oral contraceptive drugs in the treatment of acne vulgaris in females, I believe it is important to bring to the attention of all dermatologists the fact that these medications, containing a relatively high dose of estrogen, can effect epiphyseal closure and cessation of growth. High doses of estrogen have in fact been used for this purpose in unusually tall girls; the epiphyseal closure may occur after only a few months of medication, and is of course irreversible. For this reason it is imperative not to use these medications in adolescent girls in whom further skeleton growth is desirable.
Berger RA. ON USE OF ORAL CONTRACEPTIVE DRUGS IN ACNE. Arch Dermatol. 1964;89(6):898. doi:10.1001/archderm.1964.01590300126031
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