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The observations of Fregert and Rorsman, reported in this issue, raise some fundamental questions regarding problems in cutaneous hypersensitivity in general, as well as the pathogenesis of chromium hypersensitivity in particular. It is appropriate to comment on their findings at this time.
Unlike many previous reports, the authors have demonstrated that their dichromate hypersensitive subjects reacted to the intracutaneous injections of a trivalent chromium salt and 65% of the same subjects reacted to patch tests with the same salt. The observations were well controlled, and the concentrations employed were in a range well below the irritating level. The intracutaneous method of testing with trivalent compounds has not been used previously except by Mali, who found that two bichromate hypersensitive subjects were not reactive, while 40 bichromate hypersensitive patients reacted uniformly to the intradermal injection of 0.1% of the bichromate. Samitz and his group, who tested 12 patients with proven dichromate
Chromium Hypersensitivity. Arch Dermatol. 1964;90(1):2–3. doi:10.1001/archderm.1964.01600010008002
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