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July 1964


Arch Dermatol. 1964;90(1):113-115. doi:10.1001/archderm.1964.01600010119032

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Generalized Scleroderma. Presented by Drs. P. J. Koblenzer and Maarten Sabinga.  This is a 6-month old boy, weighing 10 lb (4.5 kg), with striking facial features reminiscent of progeria. Within a few days after birth the skin on the anterior abdominal wall began to be boggy and thickened, and the baby began to vomit frequently. At home during the next 3½ weeks the vomiting continued, and the skin changes appeared to progress. Also diarrhea became a troublesome symptom. He was hospitalized at a local hospital for one month and extensive blood and x-ray studies failed to reveal any abnormalities. A skin biopsy was interpreted as normal and the diagnosis of sclerema was made. Prednisone was used for two weeks without improvement in the appearance of the skin, and diarrhea and vomiting continued.At 4 months of age he was admitted to Children's Hospital of Philadelphia. Examination of the skin showed

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