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July 1964


Arch Dermatol. 1964;90(1):123-124. doi:10.1001/archderm.1964.01600010129037

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Diagnosis: Reticulum Cell Sarcoma of the Skin With Alopecia Mucinosa. Presented by Drs. Norman Orentreich, Robert Berger, and Robert Auerbach.  The patient is a 47-year-old white housewife who had generalized pruritus for three months in the spring of 1962 without any visible skin lesions. Shortly thereafter, the skin became red and scaly. Diagnoses of atopic and contact dermatitis were entertained at the time. She was treated with systemic steroids, systemic antihistamines, intravenous calcium gluconate, and at one time, aminopterin (0.5 mg for 11 days). During this period she had abscesses in the perineal areas which were treated with Staphcillin and broad-spectrum antibiotics. Early in 1963 she rapidly developed universal alopecia.When first seen by us on April 18, 1963, the patient had generalized involvement of the skin with a thickened, erythematous, scaly process that was studded with scattered, plaquelike infiltrations. Diffuse infiltration on the face imparted a leonine appearance. Hair

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