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August 1964


Arch Dermatol. 1964;90(2):252-254. doi:10.1001/archderm.1964.01600020120032

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Virilizing Adrenal Hyperplasia With Male Pattern Alopecia and Hirsutism. Presented by Drs. Robert Berger and Norman Orentreich.  The patient is a white woman, now 32 years old. Virilization was first recognized at the age of 6, when precocious development of secondary sexual characteristics were noted. A laparotomy in childhood revealed bilateral adrenal hyperplasia without adenomata. Loss of hair in a male pattern began at age 12 years. The time of onset of hirsutism on the face, trunk, and extremities is more difficult to establish. Menarche occurred at age 14, the periods being very irregular until age 18, and not entirely regular until the institution of cortisone therapy at age 23. Since that age, the patient has been maintained on relatively low doses of oral steroids. For the past three years she has been on methylprednisolone (6-7 mg daily). The patient states that this therapy has caused arrest, but not improvement,

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