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January 1965


Arch Dermatol. 1965;91(1):89-90. doi:10.1001/archderm.1965.01600070095019

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Hailey-Hailey Disease. Presented by Dr. John T. McCarthy. 

History.—  A 59-year-old woman from Puerto Rico was well until approximately two years ago when she developed pruritic blisters of the axillae, inframammary, and crural areas. Lesions have waxed and waned and have received no therapy. There is no history of drug ingestion or prior drug sensitivity. No mucous membrane lesions have been present.

Examination.—  Flaccid 0.5 to 0.8 cm pustules of the axillae, groin, and inframammary areas are evident.

Laboratory.—  Bacterial and mycologic cultures were negative. STS was negative. Biopsy of the lesions revealed a subcorneal pustule with acantholysis.

Discussion  Dr. Jack Wolf: I interpret the pustular element as secondary to maceration, a secondary manifestation in Hailey-Hailey rather than the reverse to consider it a so-called subcorneal pustular dermatosis simulating Hailey-Hailey.The locations and the involvement are such that it would appear to follow the clinical picture of Hailey-Hailey. The

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