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April 1965

Tolnaftate, a Potent Topical Antifungal Agent

Author Affiliations


From the Division of Dermatology, Department of Medicine, University of Maryland School of Medicine.

Arch Dermatol. 1965;91(4):372-376. doi:10.1001/archderm.1965.01600100088024

Tolnaftate solution (0.5% and 1.0%) is effective in the treatment of superficial mycotic infections due to Trichophyton rubrum, T mentagrophytes, Epidermophyton floccosum, Microsporum canis, T tonsurans, and Malassezia furfur.

When the diagnosis of a mycotic infection is established from scrapings and cultures, relief from itching is produced by topical applications in from 24 to 72 hours.

Interdigital infections due to T rubrum, T mentagrophytes, and E floccosum are cleared in 7 to 21 days.

Tolnaftate solution was of no value in the treatment of Candida albicans infections, scalp and nail lesions.

In vitro, tolnaftate solution has antifungal activity against M gypseum, T rubrum, M canis, E floccosum, T tonsurans, M audouini, and T mentagrophytes, but not against Penicillium notatum, Aspergillus niger, or C albicans.

In vitro studies indicate that tolnaftate solution has fungicidal as well as fungistatic activity.

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