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April 1965

Physiologic Changes In Vitiligo

Author Affiliations


From the Section of Dermatology, Department of Medicine, Yale University School of Medicine. Clinical trainee of USPHS grant No. 2T1 AM 5264 (Dr. Lerner).

Arch Dermatol. 1965;91(4):390-396. doi:10.1001/archderm.1965.01600100106027

We compared normal and vitiliginous areas and found: (a) surface temperature was increased; (b) sweat production was increased; (c) bleeding time was prolonged and the quantity of bleeding was increased.

In both normal and vitiliginous areas, responses to locally administered acetylcholine, epinephrine, and histamine were similar.

These resuts suggest that there is enhanced cholinergic activity in vitiliginous skin. This may be a direct effect of increased local acetylcholine concentration due either to increased secretion or delayed local clearing. On the other hand, this cholinergic activity may be due to relatively diminished local epinephrine and I-norepinephrine resulting from decreased secretion or a more rapid clearing of these sympathomimetic amines. The actual mechanism remains to be clarified.