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April 1965

A Study of the Lesion of Vitiligo

Author Affiliations


Present address: Department of Dermatology, All India Institute of Medical Sciences, New Delhi 16, India.

Arch Dermatol. 1965;91(4):397-404. doi:10.1001/archderm.1965.01600100113028

Depigmented skin of vitiligo patients was found not to differ significantly from normally pigmented skin with regard to cutaneous sensation, insensible perspiration and sweat gland secretion in response to intradermally injected acetylcholine.

Epidermodermal trauma resulted in depigmentation of the pigmented skin of vitiligo patients in a greater proportion of instances than in the normally pigmented skin of healthy subjects. Epidermal trauma alone seemed incapable of producing depigmentation in the pigmented skin of vitiligo patients. There was no appreciable difference in reactivity to cashew nut oil, a potent contactant, between vitiliginous skin and pigmented skin at a distant site in the same patient.

The results of full- and split-thickness exchange-transplant studies are discussed.

Histological sections from the border of some early vitiligo lesions showed tiny "vesicles" containing inflammatory cells at the dermoepidermal border.

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