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May 1965

Creeping Eruption Treated With Thiabendazole

Author Affiliations


Members of the Jacksonville Dermatology Society; Jack Bowen, MD; William Croom, MD; Marvin Engel, MD; William Eyster, MD; Joseph Farrington, MD; William Garvin, MD; Louis Hubener, MD; William Lawson, MD; Lauren Sompayrac, MD; and James Trimble, MD.

Arch Dermatol. 1965;91(5):425-426. doi:10.1001/archderm.1965.01600110011003

Members of the Jacksonville Dermatology Society have treated 51 patients with active creeping eruption with oral thiabendazole. No single- or double-blind placebo controls were used. There were no severe toxic reactions from the drug in the dosage of 25 mg/kg of body weight twice a day. Observation during the patients' hospitalization and results of their laboratory tests lead us to believe that thiabendazole is a relatively safe drug and might be given without hospitalization of the patient. Our results to date have been encouraging for a disease that hitherto has had no satisfactory treatment. Even the seven cases that did not respond entirely received no less than a "good" rating by both doctor and patient. The posttreatment follow-up ranged from one week to one month. During this time none of 44 responsive patients developed relapses of their disease. In our program 25 mg/kg of body weight for 3 to 4 days seems the best treatment schedule.