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To the Editor:
The finding of ``amyloid-like material'' in 16 out of 26 examples of calcifying epithelioma of Malherbe by Peterson, W. C., Jr., and Hult, A. (Arch Derm 90:404-410 [Oct] 1964) is interesting. Two previous reports (Freudenthal, W.: Amyloid in der Haut, Arch Derm Syph 162:40, 1930, and Malak, J. A., and Smith, E. W.: Secondary Localized Cutaneous Amyloidosis, Arch Derm 86:465-477, 1962) have shown amyloid deposits in the vicinity of cutaneous epitheliomas in an incidence of about 8% and 11%, respectively. This localized deposition of amyloid in the skin in association with other cutaneous lesions, but in the absence of systemic deposition, has been referred to as secondary localized cutaneous amyloidosis, in contradistinction to primary localized cutaneous amyloidosis (lichen amyloidosis), where no predisposing or associated localized cutaneous lesion has so far been reported.To date, the diagnosis of amyloidosis remains primarily histochemical. It is basically on positive staining
Malak JA. AMYLOID IN CALCIFYING EPITHELIOMA. Arch Dermatol. 1965;91(5):570. doi:10.1001/archderm.1965.01600110156025
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