Patients with psoriasis receiving cytotoxic drug therapy and appropriate control subjects were exposed to (1) sensitizing doses of delayed allergens, dinitrochlorobenzene (DNCB), and paranitrosodimethylaniline (NDMA); (2) evocative patches of pentadecylcatechol (PDC); and (3) immunizing doses of a plague vaccine. Psoriatic patients so treated were very difficult to sensitize to DNCB and NDMA, reacted normally to PDC, and generally failed to give a primary or a secondary immune response to plague antigen.
EPSTEIN WL, MAIBACH HI. Immunologic Competence of Patients With Psoriasis Receiving Cytotoxic Drug Therapy. Arch Dermatol. 1965;91(6):599–606. doi:10.1001/archderm.1965.01600120031006
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