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Article
June 1965

Experimental Cutaneous Histoplasmosis in Hamsters

Author Affiliations

CINCINNATI

From the Clinical Laboratories, Jewish Hospital, and the laboratory of Mycology (departments of pathology and dermatology) College of Medicine, University of Cincinnati.

Arch Dermatol. 1965;91(6):645-656. doi:10.1001/archderm.1965.01600120077021
Abstract

After subcutaneous injection of Histoplasma capsulatum into hamsters, a primary complex (cutaneous lesion plus involvement of regional lymphnodes) developed with regularity. The ensuing hematogenous spread was governed primarily by the invasiveness of the individual strains. Primary cutaneous histoplasmosis provided only partial protection to challenge with the same organism. Human cutaneous infections with fungi are acceptable as primary only if a chancre with regional lymphnodes is demonstrated in conjunction with traumatic inoculation.

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