[Skip to Content]
[Skip to Content Landing]
Article
June 1965

Dimethylsulfoxide (DMSO) Induction of a Steroid Reservoir in Human Skin

Author Affiliations

CLEVELAND

Director of Dermatology-Western Reserve University.

Arch Dermatol. 1965;91(6):657-660. doi:10.1001/archderm.1965.01600120089022
Abstract

Within a few minutes after application to the surface of human skin, hydrocortisone and fluocinolone acetonide in the presence of dimethylsulfoxide (DMSO) are established in a protected reservoir in the stratum corneum. This reservoir remains over a 16 day period and is resistant to washing of the skin surface with soap, water, and alcohol.

×