Within a few minutes after application to the surface of human skin, hydrocortisone and fluocinolone acetonide in the presence of dimethylsulfoxide (DMSO) are established in a protected reservoir in the stratum corneum. This reservoir remains over a 16 day period and is resistant to washing of the skin surface with soap, water, and alcohol.
STOUGHTON RB. Dimethylsulfoxide (DMSO) Induction of a Steroid Reservoir in Human Skin. Arch Dermatol. 1965;91(6):657–660. doi:10.1001/archderm.1965.01600120089022
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